The Role of Mitosis and Miosis In Cancer Tistes Antigen (CTA) Literature review - 1

The Role of Mitosis and Miosis In Cancer Tistes Antigen (CTA) - Literature review Example In this work called "The Role of Mitosis and Meiosis in Cancer Testis Antigen (CTA)" author overviews the connection between differentiation failure and cancer development in patients with testis cancer. Division of germ cells has special features that make this illness distinguished in comparison with the other groups of cancer diseases. It is a well-known fact that the germ cell line derives from the primordial germ cells. These cells basically migrate through the dorsal mesentery of the embryo and then enter the fetal gonad that is developing in the genital ridge. In males, in this genital ridge, the primordial germ cells are enclosed by somatic Sertoli cells and are known as prospermatogonia. These proliferate for a few days and then rest at G0 or G1 of cell cycle until puberty. When the individual attains puberty, the proliferation of the prospermatogonia resumes, thus initiating spermatogenesis. Spermatogonia are the male germline stem cells and they proliferate from puberty al l through the adult life. Two meoitic divisions are involved in this step and a tetraploid of primary spermatocytes are first formed which further undergo meiosis to form haploid sperms. Cancer Testis Antigens or CTAs like MAGE and NY-ESO-1 are basically expressed in these spermatogonia. This tiny investigation is aimed at defining role reasons of CT development in patients, who are included in the high-risk group. Tables, statistics and scientific evidence-based argumentation without any doubt will help you to get the highest A!